The 7.6 million budget hotel will be situated on the promenade.
The seafront hotel has got the go ahead despite existing hoteliers in the area speaking out against it.
Blackpool Council’s planning committee approved the application by a small majority.
EasyHotel, part of the easyJet group, will now build a 107-bedroom property on an empty plot of land on the Promenade in South Shore.
31 rooms from the proposed hotel will not have a window.
Ian White, speaking on behalf of hoteliers group StayBlackpool said:
“Blackpool is already saturated with low end accommodation and all the projects undertaken so far have been about attracting better quality visitors.
“So this is going against everything the council is trying to encourage in this town.
Representatives from easyHotel, which has venues across Europe, including in the UK from £16.99 per night, assured councillors the rooms would still be high quality.
The company’s agent Philip Grant said:
“It is budget accommodation, but good quality and not just intended to attract visitors.
“It is considered to be good quality affordable accommodation that would allow guests to spend more money in the area.”
There has also been concerns over the lack of parking in the area.